Short term outcomes of breast conserving surgery in breast cancer after neoadjuvant therapy.

Abstract

Objective: To determine the short term outcomes of BCS after neo-adjuvant therapy in patients with carcinoma of breast. Study Design: Descriptive Case Series. Setting: Surgical Wards, Mayo Hospital, Lahore. Period: February 2020 to August 2020. Methods: This study was performed in 41 patients having breast lump, fulfilling inclusion criteria presented in outdoor of surgical department of Mayo Hospital Lahore with ethical approval on 10-01-2020. Before neo-adjuvant chemotherapy, clips were positioned in the breast at the site of lump. Immediate mammogram was obtained after that, to confirm clips position. Patients underwent pre planned cycles of chemotherapy and then was restaged after chemotherapy. Response to chemotherapy evaluated clinically, radiologically and on resected specimen all the information was noted on predesigned proforma. Data Analyzed through SPSS version 26. Results: Mean age of the patients diagnosed with carcinoma of breast fall in the age group 31-35 (Mean age 35 ± SD 1.456). More than 80% of the tumors came out to be invasive ductal carcinomas of breast with majority (about 65%) in the upper outer quadrant of breast. About 42% and 44% of the patients showed complete and partial clinical response respectively. In this study 17% of the patients showed no pathological response after chemotherapy. About 54% and 29% of the patients showed partial pathological response and complete pathological response respectively. About 100% of the tumors excised were having margins free of tumor. Conclusion: Based on the results of our study it can be concluded that breast conserving surgery after neo-adjuvant chemotherapy is choice of treatment with good short term outcomes, eradicating the need for mastectomy depending on response to chemotherapy.