Dorzolamide / timolol and brinzolamide / brimonidine fixed combination topical drug therapy tn the management of intraocular pressure in primary open angle glaucoma.

Authors

  • Fauzan Ayub Mayo Hospital, Lahore.
  • Sidrah Latif King Edward Medical University, Lahore.
  • Hafsa Latif Mayo Hospital, Lahore.
  • Sidra Ahsan Shah Mayo Hospital, Lahore.
  • Saman Ali
  • Muhammad Qasim Yazar Mayo Hospital, Lahore.

DOI:

https://doi.org/10.29309/TPMJ/2025.32.10.9816

Keywords:

Primary Open-angle Glaucoma, Intraocular Pressure, Dorzolamide/timolol, Brinzolamide/brimonidine

Abstract

Objective: To compare the mean change in intraocular pressure (IOP) achieved with dorzolamide/timolol versus brinzolamide/brimonidine fixed combination topical therapy in patients diagnosed with primary open-angle glaucoma (POAG). Study Design: Randomized Control Trial. Setting: Department of Ophthalmology, Mayo Hospital, Lahore. Period: May’2024 to October’2024. Methods: A total of 60 cases aged 40–70 years with primary open-angle glaucoma were included and randomly assigned to receive either dorzolamide/timolol (Group X) or brinzolamide/brimonidine (Group Y). IOP was measured weekly for four weeks using Goldman tonometry, with the primary outcome being mean IOP reduction at week four. Results: The mean baseline IOP was comparable in both groups (p=0.947). After 4 weeks, IOP reduction was significantly greater in Group Y (6.84 ± 2.34 mmHg) than Group X (5.37 ± 2.16 mmHg) (p=0.014). Stratified analysis showed a significant IOP reduction in older patients (56–70 years) and in females treated with brinzolamide/brimonidine (p=0.006 and p=0.049, respectively). Conclusion: Brinzolamide/brimonidine fixed combination therapy was more effective in reducing IOP than dorzolamide/timolol, especially in older patients and females, suggesting a potential demographic influence on drug response.

Author Biographies

Fauzan Ayub, Mayo Hospital, Lahore.

MBBS, PG Trainee Eye, 

Sidrah Latif, King Edward Medical University, Lahore.

MBBS, FCPS, FRCO phth, MRCS ED, MRCPSG, Assistant Professor Ophthalmology, 

Hafsa Latif, Mayo Hospital, Lahore.

MBBS, BSc, FCPS (Ophthalmology), Post Graduate Resident, 

Sidra Ahsan Shah, Mayo Hospital, Lahore.

MBBS, PGR Trainee, 

Saman Ali

MS (Ophthalmology), APWMO/ Glaucoma Clinic Incharge

Muhammad Qasim Yazar, Mayo Hospital, Lahore.

MBBS, FCPS (Ophthalmology), PGR Eye Unit 3, 

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Published

2025-10-02

Issue

Section

Origianl Article