Outcomes of delayed vs early cholecystectomy in individuals diagnosed with acute biliary pancreatitis caused by gallstones.

Authors

  • Rabel Qureshi Jinnah Postgraduate Medical Centre, Karachi.
  • Beenish Khan Jinnah Postgraduate Medical Centre, Karachi.
  • Rakesh Kumar Al Amiri Hospital Kuwait.
  • Priya Mandhan Trauma Hospital PECHS, Karachi.
  • Adil Dawach Jinnah Postgraduate Medical Centre, Karachi.
  • Ashfaq Hussain Memon Sohail Trust University Hospital, Karachi.

DOI:

https://doi.org/10.29309/TPMJ/2025.32.10.9618

Keywords:

Acute Biliary Pancreatitis, Biliary Leakage, Cholecystectomy, Hospital Stay

Abstract

Objective: To conduct a comparative analysis of the outcomes associated with delayed cholecystectomy vs early cholecystectomy in individuals diagnosed with acute biliary pancreatitis caused by gallstones. Study Design: Randomized Clinical Trial. Setting: Department of General Surgery, Jinnah Postgraduate Medical Centre in Karachi, Pakistan. Period: March 2023 to August 2023. Methods: A total of 120 patients with mild to severe acute biliary pancreatitis were randomized into two groups: Group EC (early cholecystectomy) and Group DC (delayed cholecystectomy). Biliary leakage incidence and hospital stay duration were recorded. Chi-square and independent t-tests were used to analyze differences between groups, with a p-value <0.05 considered statistically significant. Results: The average age of the patients enrolled was 46.33 + 12.92 years. 62 (51.67%) were female, while 58 (48.33%) were male. The average dimension of gallstones was 6.65 x 2.37 mm. The average quantity of gallstones was 2.65 + 2.63. Patients who underwent delayed cholecystectomy spent an average of 5.47 days in the hospital, whereas those who underwent early cholecystectomy spent 4.351.18 days (p-value <0.0001). Biliary leakage was observed in three patients (5.0%) who underwent early cholecystectomy, compared to ten patients (16.7%) who underwent delayed cholecystectomy (p-value = 0.04). Conclusion: There is a correlation between early laparoscopic cholecystectomy and a reduced incidence of biliary leakage as well as a shorter duration of hospitalization. Patients with acute biliary pancreatitis may therefore safely undergo an early laparoscopic approach. 

Author Biographies

Rabel Qureshi, Jinnah Postgraduate Medical Centre, Karachi.

MBBS, FCPS (General Surgery), Consultant General Surgeon, Surgical Ward-III, 

Beenish Khan, Jinnah Postgraduate Medical Centre, Karachi.

MBBS, FCPS, Senior Registrar Ward 2, 

Rakesh Kumar, Al Amiri Hospital Kuwait.

MBBS, FCPS Registrar General Surgery, 

Priya Mandhan, Trauma Hospital PECHS, Karachi.

MBBS, FCPS, Royal Institute of Medicine & Surgery (Rims) Hospital, 

Adil Dawach, Jinnah Postgraduate Medical Centre, Karachi.

MBBS, FCPS (General Surgery), Consultant General Surgeon, 

Ashfaq Hussain Memon, Sohail Trust University Hospital, Karachi.

MBBS, FCPS, Senior Registrar, 

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Published

2025-10-02

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Section

Origianl Article