Comparison of postoperative infection rates by use of single-dose with multiple-doses of prophylactic antibiotics in thyroidectomy.

Authors

  • Muhammad Zafar Mengal Narowal Medical College/Teaching Hospital, Narowal.
  • Muhammad Najam Iqbal Quaid I Azam Medical College/BVH, Bahawalpur.
  • Muhammad Anwar Quaid I Azam Medical College/BVH, Bahawalpur.
  • Uzma Shaheen Narowal Medical College/Teaching Hospital, Narowal.
  • Muhammad Muneeb Saqlain Bajwa Narowal Medical College/Teaching Hospital, Narowal.
  • Rehan Hameed Narowal Medical College/Teaching Hospital, Narowal.

DOI:

https://doi.org/10.29309/TPMJ/2025.32.08.9177

Keywords:

Multiple-Doses, Postoperative Infection Rate, Prophylactic Antibiotics, Single-Dose, Thyroidectomy

Abstract

Objective: To compare the postoperative wound infection rates in thyroidectomy patients receiving single-dose prophylactic antibiotics and multiple-dose regimens. Study Design: Prospective, Randomized Controlled Trial. Setting: Surgical Ward, Narowal Medical College/DHQ Teaching Hospital, Narowal. Period: 1st January 2024 to 31st December 2024. Methods: Patients undergoing elective thyroidectomy were randomized divided into two groups: Group A (single-dose) received a single ceftriaxone (1.0 g IV) 30 minutes before incision, and Group B (multiple-dose) received the same initial dose followed by three additional doses every 8 hours for 24 hours after surgery. Postoperative infections were evaluated on days 3, 7, and 30. Statistical analysis was performed using chi-square tests for categorical variables and t-tests for continuous variables. Results: A total of 200 patients were enrolled, with 100 in each group. Among them 156 were females and 44 were male with male to female ratio was 78:22 percent (3.54: 1). The overall infection rate was 2% (4/200). Group A had an infection rate of 3% (3/100), while Group B had an infection rate of 1% (1/100), with no statistically significant difference (p = 0.312. The cost of antibiotic therapy was significantly lower in Group A (P < 0.001). Conclusion: Single-dose prophylactic antibiotics are as effective as multiple-dose regimens in preventing postoperative infections in thyroidectomy, and lower costs.

Author Biographies

Muhammad Zafar Mengal, Narowal Medical College/Teaching Hospital, Narowal.

MBBS, MS, FCPS, FCTS, Associate Professor Surgery, 

Muhammad Najam Iqbal, Quaid I Azam Medical College/BVH, Bahawalpur.

MBBS, FCPS, Associate Professor Surgery, 

Muhammad Anwar, Quaid I Azam Medical College/BVH, Bahawalpur.

MBBS, FCPS, Assistant Professor Surgery. 

Uzma Shaheen, Narowal Medical College/Teaching Hospital, Narowal.

MBBS, FCPS, Assistant Professor Surgery

Muhammad Muneeb Saqlain Bajwa, Narowal Medical College/Teaching Hospital, Narowal.

MBBS, MS, Senior Registrar Surgery, 

Rehan Hameed, Narowal Medical College/Teaching Hospital, Narowal.

MBBS, FCPS, Assistant Professor Surgery, 

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Published

2025-07-30

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Section

Origianl Article