Comparison of outcome in patients undergoing elective cesarean delivery with intravenous acetaminophen versus placebo.

Abstract

Objective: To see effect of IV acetaminophen in post caesarean delivery to control pain in cases with general anesthesia. Study Design: Randomized Controlled Trail. Setting: Department of Obstetrics and Gynecology, University Teaching Hospital, Gujranwala. Period: Aug 31, 2019 till April 30, 2020. Methods: All cases meeting inclusion criteria was enrolled and underwent elective cesarean section. Then they were randomly divided to receive either 15 mg/kg intravenous acetaminophen (n = 146) or normal saline (n = 146) fifteen minutes before endotracheal intubation. Pain was measured after 6 hours of C-section. SPSS version 22 was used to analyze the data. Results: The mean age of cases in group-A was 26.59 ± 4.95 years and in group-B was 26.44 ± 4.72 years. The mean gestational age in group-A and group-B was 39.54 ± 1.19 weeks and 39.38 ± 1.08 weeks. The mean pain in group-A was 4.98 ± 1.01 and in group-B was the mean pain was 6.18 ±1.30. The mean pain in group-A (acetaminophen group) was statistically lower than group-B (placebo), p-value < 0.001. Conclusion: It is concluded that IV acetaminophen is effective in controlling the pain in cases with general anesthesia after caesarean delivery. Hence in future this non-opioid analgesic without potential adverse effects can be used. This will surely reduce the analgesia requirement and hospital stay.