Comparison of outcome in patients undergoing elective cesarean delivery with intravenous acetaminophen versus placebo.

Authors

  • Ammara Shakeel National Hospital and Medical Center, Lahore.
  • Sadaf Aziz Lady Willigdon Hospital, Lahore.
  • Bushra Shakeel City Hospital Multan.
  • Maryam Naeem University Teaching Hospital Gujranwala/GMC Gujranwala.
  • Wajiha Irfan Combined Military Hospital Multan affiliated with College of Physicians and Surgeons Pakistan.
  • Rao Nouman Ali DHQ Hospital, Khanewal.

DOI:

https://doi.org/10.29309/TPMJ/2025.32.06.8808

Keywords:

Analgesia Requirement, Caesarean Delivery Pain, IV Acetaminophen, Pain Control

Abstract

Objective: To see effect of IV acetaminophen in post caesarean delivery to control pain in cases with general anesthesia. Study Design: Randomized Controlled Trail. Setting: Department of Obstetrics and Gynecology, University Teaching Hospital, Gujranwala. Period: Aug 31, 2019 till April 30, 2020. Methods: All cases meeting inclusion criteria was enrolled and underwent elective cesarean section. Then they were randomly divided to receive either 15 mg/kg intravenous acetaminophen (n = 146) or normal saline (n = 146) fifteen minutes before endotracheal intubation. Pain was measured after 6 hours of C-section. SPSS version 22 was used to analyze the data. Results: The mean age of cases in group-A was 26.59 ± 4.95 years and in group-B was 26.44 ± 4.72 years. The mean gestational age in group-A and group-B was 39.54 ± 1.19 weeks and 39.38 ± 1.08 weeks. The mean pain in group-A was 4.98 ± 1.01 and in group-B was the mean pain was 6.18 ±1.30. The mean pain in group-A (acetaminophen group) was statistically lower than group-B (placebo), p-value < 0.001. Conclusion: It is concluded that IV acetaminophen is effective in controlling the pain in cases with general anesthesia after caesarean delivery. Hence in future this non-opioid analgesic without potential adverse effects can be used. This will surely reduce the analgesia requirement and hospital stay.

Author Biographies

Ammara Shakeel, National Hospital and Medical Center, Lahore.

MBBS, FCPS, Consultant Gynecologist, 

Sadaf Aziz, Lady Willigdon Hospital, Lahore.

MBBS, FCPS, Consultant Gynecologist, 

Bushra Shakeel, City Hospital Multan.

MBBS, FCPS, Consultant Gynecologist, 

Maryam Naeem, University Teaching Hospital Gujranwala/GMC Gujranwala.

MBBS, FCPS, Senior Registrar Gynecology, 

Wajiha Irfan, Combined Military Hospital Multan affiliated with College of Physicians and Surgeons Pakistan.

MBBS, FCPS, Registrar Radiology, 

Rao Nouman Ali, DHQ Hospital, Khanewal.

MBBS, FCPS, Consultant Urology, 

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Published

2025-06-01

Issue

Section

Origianl Article