DIABETIC FOOT INFECTION

FREQUENCY OF MICROBES AND ANTIMICROBIAL SENSITIVITY PATTERN AT TERTIARY CARE HOSPITAL, KARACHI

Abstract

Objectives: To determine the frequency of common bacterial isolates cultured
from diabetic foot infection in patients with type 2 diabetes mellitus (DM) falling in Wagner’s
grade-2 and grade-3 classification of diabetic foot (DF) infection. Study Design: Descriptive
study. Period: A six months. Setting: Dow University of health sciences and civil hospital Karachi.
Methods: Completed to examine the bacterial identification in cases admitted with the infection
diabetic foot along with gave Wagner’s evaluation 2 and 3 at tertiary care hospital Karachi.
Bacteriological finding and anti-biotic affectability profiles were completed and analyzed with
utilizing standard strategies. Results: Out of 115 cases, 82 (71%) were male and 23 (29%) were
female. The mean age of patients was 51.7 ±9.45 years, mean duration of diabetes was 10.6
± 4.73 years, similarly mean length of time of diabetes foot wound was 46.15±23.75 days. 45
(39%) patients had Wegner’s evaluation 2 and 70 (61%) patients had Wagner’s evaluation 3. 99
cases indicated with culture growth, out of which 65 (65.65%) with gram negative microbes and
25 (25.25%) gram-positive microbes. The most successive bacteria’s were Proteus (35.35%),
Staph. Aureus (25.25%), Klebsiella (16.16%) and Pseudomonas (15.15%). Both gram positive
and gram negative showed frequent resistance to Cloxacillin, Amoxacillin, Levofloxacin, and
Linezolid, gram negative life forms likewise indicated high resistance rate to Clindamycin,
Vancomycin, and Cefotaxime. Tienam (Imipenem), Sulzone (salbactam in addition to
cefoperazone) and Amikacin were the best effective against gram -ve and gram +vemicrobes.
Staph. Aureus and Staph. Epidermidis were profoundly susceptible to Ciprofloxacin, Ceftriaxone,
Clindamycin, and Vancomycin. Conclusion: Gram negative microbes were more common than
gram positive living beings. Proteus, Staph Aureus, Klebsiella and Pseudomonas aeruginosa
were the most widely recognized microorganisms of DF infection. Tienam (Imipenem), Sulzone
(salbactam in addition to cefoperazone), and Amikacin were best effective agents.