PRE-ECLAMPSIA

LEPTIN IN PRE-ECLAMPSIA IN THIRD TRIMESTER OF PREGNANCY A HOSPITAL BASED TRIAL

Abstract

Objectives: To determine the relation of leptin, hypertension and body mass
index with pre-eclampsia in the 3rd trimester of pregnancy in a hospital based study. Design:
descriptive observational study. Setting: three teaching hospital of Peshawar, Khyber teaching
hospital, Hayatabad medical complex and lady reading hospital Peshawar. Duration: June
2012-dec 2012. Inclusion criteria: all women in their third trimester without any co-morbidity.
Exclusion criteria: were all diabetic and first and 2nd trimester pregnant ladies. Procedure:
relevant information on height, weight, body mass index (BMI), pulse, blood pressure and leptin
were recorded on a predesigned questionnaire prepared in accordance with the objectives
of the study. Data was analyzed in MS-Excel. Results: A total of 80 pregnant ladies included.
Majority of the patients were in the age range of 17-26 years of age. Maximum number 30(37.5%)
of patients were in weight ranging 66-75 kg. We observed maximum number of patients were
normotensive systolic BP 110-130mmHg (47%). About 43% of patients had BP>140mmHg up
to 200mmHg. 6% had Diasatolic BP between 130-140mmHg. 23.5% had BMI>32.6. 38% had
BMI between 27.62-32.62. We observed that majority of the patients were in the leptin serum
range of 229.57-329.57. 7.75% had serum leptin level above 329 with a maximum of 829.6
in one patient at top in data. Conclusion: Serum leptin level in pregnancy increases in third
trimester with a determined relation of serum leptin level with gestaional hypertension and preeclampsia.