Efficacy of Vitamin E Versus Pioglitazone in Treating Non-Alcoholic Fatty Liver Disease (NAFLD) without Diabetes “Decoding the Exodus of Liver Health”.

Authors

  • Muhammad Owais Fazal FMU.
  • Ghulam Abbas Tahir AHF.
  • Yasir Yaqoob AHF.
  • Ahmad Zeeshan AHF.
  • Rabia Sharif AHF.
  • Muhammad Usman Musharraf AHF.

DOI:

https://doi.org/10.29309/TPMJ/2024.31.12.8405

Keywords:

Efficacy, Non-alcoholic Fatty Liver Disease, Non-diabetics, Pioglitazone, Vitamin E

Abstract

Objective: To compare the effectiveness of vitamin E in comparison with Pioglitazone in the management of NAFLD without Diabetes. Study Design: Randomized Control Trial. Setting: Outpatient Department of Allied Hospital, Faisalabad. Period: Dec 2023 to May 2024. Methods: The Ethics Review Committee of Faisalabad Medical University was taken on board and patients having the characteristics of the set Inclusion Criteria were enrolled as allowed. Selected individuals were counseled regarding the study and their consent was sought. Using a computer-generated random number table, two main groups were formed out of the participants, Group A and Group B. Group A was given 800IU of Vitamin E daily. Group B received Pioglitazone 30mg daily. Patients were monitored for efficacy over three months by tracking ALT levels as specified in the operational definition. Follow-up was ensured through contact numbers. Results: In our study of 722 cases (361 in each group), the mean age was 41.25±6.41 years in Group A and 41.23±6.56 years in Group B. Males comprised 60.11% (n=217) of Group A and 59.56% (n=215) of the Group B, while females accounted for 39.89% (n=144) out of Group A and 40.44% (n=146) of the Group B. Efficacy comparison showed that 49.72% (n=147) in Group A and 31.30% (n=113) in Group B achieved efficacy, with a p-value of 0.008, pointing out a considerable difference. Conclusion: Our study succeeded in establishing the better efficacy of Vitamin E in treating NAFLD compared to Pioglitazone.

Author Biographies

Muhammad Owais Fazal, FMU.

MBBS, MCPS (Med), FCPS (Med) MRCP (Glasg UK), PG DIP (Diabetes), CHPE, MBA (IRE), MSPH, Associate Professor, 

Ghulam Abbas Tahir, AHF.

MBBS, FCPS (Med), CHPE, Assistant Professor Medicine, 

Yasir Yaqoob, AHF.

MBBS, FCPS (Med), Assistant Professor, 

Ahmad Zeeshan, AHF.

MBBS, FCPS (Med), Assistant Professor, 

Rabia Sharif, AHF.

MBS, FCPS (Gyn/Obs), Senior Registrar, 

Muhammad Usman Musharraf, AHF.

MBBS, FCPS (Med), FCPS (Endo), Senior Registrar Medicine, 

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Published

2024-12-01