Frequency of Ceftazidime-Avibactam resistance in Pseudomonas aeruginosa: Experience at a Tertiary Care Hospital.

Authors

  • Mahnoor Chaudhry Shalamar Medical and Dental College, Lahore.
  • Kokab Jabeen Sahiwal Medical College, Sahiwal.
  • Zainab Tufail Lahore General Hospital, Lahore.
  • Sana Mustafa Lahore General Hospital, Lahore.
  • Seerat Fatima Tu Zahra Shalamar Medical and Dental College, Lahore.
  • Sara Mahmood Fatima Memorial Medical and Dental College, Lahore.

DOI:

https://doi.org/10.29309/TPMJ/2024.31.11.8312

Keywords:

Anti-microbial Resistance, Ceftazidime/Avibactam, Pseudomonas Aeruginosa

Abstract

Objective: To isolate Pseudomonas aeruginosa from different clinical samples and determine the antimicrobial activity of Ceftazidime/avibactam against these isolates. Study Design: Prospective Cross-sectional study. Setting: Pathology Laboratory of Lahore General Hospital, Lahore. Period: July 2023 to June 2024. Methods: One hundred thirteen Pseudomonas aeruginosa were identified from different samples Bacterial identification was done by gram staining, bench tests, and API20NE. The antimicrobial sensitivity testing of the causative bacteria was conducted, using commercially available discs, by Kirby Bauer disc diffusion assay and reported in accordance with Clinical & Laboratory Standards Institute (CLSI) 2022. Results: Out of 113 resistant strains of Pseudomonas aeruginosa obtained from different clinical samples Ceftazidime/avibactam was only sensitive to 43.4% of strains and resistant to 56.6% of them. Conclusion: According to the findings of this study, Pseudomonas aeruginosa, a nosocomial organism is isolated from many different clinical samples. The findings of this study also indicate that even a new combination antibiotic fails to show sensitivity in more than half of the isolates. This is a frightening situation that places stress on avoiding the misuse of antibiotics and following anti-microbial stewardship.

Author Biographies

Mahnoor Chaudhry, Shalamar Medical and Dental College, Lahore.

MBBS, M.Phil, Senior Demonstrator Microbiology, 

Kokab Jabeen, Sahiwal Medical College, Sahiwal.

MBBS, M.Phil, Ph.D, Professor Pathology, 

Zainab Tufail, Lahore General Hospital, Lahore.

MBBS, Resident Microbiology, 

Sana Mustafa, Lahore General Hospital, Lahore.

MBBS, Resident Microbiology, 

Seerat Fatima Tu Zahra, Shalamar Medical and Dental College, Lahore.

MBBS. M.Phil (Microbiology), Senior Demonstrator Pathology, 

Sara Mahmood, Fatima Memorial Medical and Dental College, Lahore.

MBBS, M.Phil (Microbiology), Senior Demonstrator Pathology, 

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Published

2024-11-03