Diagnostic role of high Sensitive-CRP and procalcitonin in hospitalized patients.

Abstract

Objective: To assess these two biomarkers' effectiveness in admitted patients of Farooq Hospital Lahore, Pakistan. Study Design: Prospective study. Setting: Farooq Hospital Westwood, Lahore. Period: November 2023 to January 2024. Methods: The admitted patients of intensive care units, medical and cardiac care units, with acute kidney infection, chronic kidney disease, diabetes mellitus, hypertension, coronary artery bypass grafting, gastroenteritis, chronic obstructive pulmonary disease, liver disease, hepatitis, and bacterial infection were included. The automated analyzers analyzed the serum albumin, high-sensitive C-reactive protein (hs-CRP), and procalcitonin. Data was analyzed by using SPSS (v.25.0). Results: Among 73 patients, 83.56% were critical and 16.44% stable. It was found that the highest critical patients were under the age of 61 to 90 years. The hs-CRP and procalcitonin levels were non-significantly correlated with age group. The hs-CRP exhibited higher sensitivity than procalcitonin in critical patients (AUC: 0.872 vs. 0.725). Likewise, serum albumin had a significant association with patients having critical conditions (AUC: 0.685). Moreover, it was found that hs-CRP and procalcitonin have a significant association with the period of patient stay in the hospital. Conclusion: The present study concluded that patients with high levels of procalcitonin and hs-CRP had longer hospital stays and that both biomarkers are equally important in the treatment of critically ill admitted patients.