Extent of iron induced organ damage in patients with hematological disorders.

Authors

  • Syeda Azka Waqar FMH, Lahore.
  • Mona Aziz Sheikh Zayed Hospital, Lahore.
  • Yumna Ather Sheikh Zayed Hospital, Lahore.
  • Amna Shoukat Sheikh Zayed Hospital, Lahore.
  • Rabia Butt Fatima Memorial Hospital, Lahore.
  • Ghazal Usman Sheikh Zayed Hospital, Lahore.

DOI:

https://doi.org/10.29309/TPMJ/2024.31.11.8202

Keywords:

Hematological Disorders, Iron Toxicity, MOF Score, Transfusion Dependent Anemia

Abstract

Objective: To determine the extent of iron induced organ damage in patients of Haematological disorders who are transfusion dependent, presenting in the emergency department of SZH, Lahore. Study Design: Cross Sectional study. Setting: Department of Emergency, Shaikh Zayed Hospital, Lahore. Period: December 25, 2020 to June 24, 2021. Methods: A total of 100 patients aged 10-60 years, of both genders, diagnosed with haematological disorders, and receiving multiple blood transfusions were included in this study. Demographic details were noted including name, age, sex, diagnosis, duration of receiving transfusions and number of transfusions received per month. Patients were evaluated clinically for organ damage including pulmonary, hepatic, renal, and cardiac organs using Denver MOF score. Results: Mean age of patients was 35.33±14.27 years. Mean duration of receiving transfusion was 6.69±2.71 months. There were 67 (67%) males and 33 (33%) female patients. Primary diagnosis was Autoimmune Haemolytic Anemia (AIHA) in 18 (18.00%) patients, Aplastic anemia in 34 (34%) patients, Thalassemia in 37 (37%) patients and Myelodysplastic syndrome (MDS) in 11 (11%) patients. Multiple organ damage was found in 23 (23%) patients. Pulmonary damage was diagnosed in 21 (21%) patients, hepatic damage in 21 (21 %) patients, renal damage in 20 (20%) patients and cardiac damage in 15 (15%) patients. Conclusion: There is a high frequency of multi-organ damage in patients of Haematological disorders requiring chronic blood transfusions. In this study, multi-organ damage was diagnosed in 23% patients requiring chronic blood transfusion.

Author Biographies

Syeda Azka Waqar, FMH, Lahore.

MBBS, FCPS, Senior Demonstrator Haematology, 

Mona Aziz, Sheikh Zayed Hospital, Lahore.

MBBS, FCPS, Professor & Head Pathology, 

Yumna Ather, Sheikh Zayed Hospital, Lahore.

MBBS, PGR Haematology, 

Amna Shoukat, Sheikh Zayed Hospital, Lahore.

MBBS, FCPS, PGR Haematology, 

Rabia Butt, Fatima Memorial Hospital, Lahore.

MBBS, FCPS, FRCPATH, Assistant Professor Histopathology, 

Ghazal Usman, Sheikh Zayed Hospital, Lahore.

MBBS, PGR Haematology, 

Downloads

Published

2024-11-03