Comparison between outcome of early and delayed laparoscopic surgery in patients with acute cholecystitis – A prospective randomized controlled trial.


  • Arrham Hai ANTH.
  • Sabah Ali Chaudhary ANTH.
  • Atiq Ur Rehman ANTH.
  • Maham Farooq ANTH.
  • Usman Akram ANTH.
  • Tahira Hameed ANTH.



Acute, Cholecystitis, Cholecystectomy, Laparoscopic, Surgical Procedure


Objective: To determine the comparison between outcome of early and delayed laparoscopic cholecystectomy among patients presenting with acute cholecystitis. Study Design: Prospective Randomized Controlled Trial. Setting: Dr. Akbar Niazi Teaching Hospital, Islamabad. Period: September 2022 to February 2023. Material & Methods: Total 108 patients (54 in each group) were included in the study. Group-A planned for surgery before 7 days of onset of symptoms, while Group-B planned for surgery after 7 days of onset of symptoms. The outcomes were measured in terms of hospital stay and operating time. Results: Patient’s age range was 15-60 years with mean age of 40.8±12.6 and 42.2±12.8 years in group-A and B, respectively. Conversion to open cholecystectomy, bile duct injury, surgical site infection and hypertension were comparable in both groups. Mean hospital stay in group-A was 9.26±2.43 and in group-B 15.41±3.37 days (p = 0.001). Mean operating time was significantly less in group-A as compared to group-B (64.93±6.68 vs 72.78±8.03 min; p = 0.001). Stratification with regard to gender and hypertension was significant (p ≤ 0.05), whereas stratification with regard to age and surgical site infection was insignificant (p ≥ 0.05). Conclusion: Early laparoscopic cholecystectomy is safe and associated with less complications and lower conversion rates as compared to late cholecystectomy for acute cholecystitis.

Author Biographies

Arrham Hai, ANTH.

MBBS, FCPS, Senior Registrar Surgery, 

Sabah Ali Chaudhary, ANTH.

MBBS, Registrar Surgery, 

Atiq Ur Rehman, ANTH.

MBBS, MS, Senior Registrar Surgery, 

Maham Farooq, ANTH.

MBBS, Post-graduate Trainee Surgery, 

Usman Akram, ANTH.

MBBS, FCPS, MRCS, Assistant Professor Surgery, 

Tahira Hameed, ANTH.

MBBS, FCPS, MRCS, Senior Registrar Surgery,