Frequency of asymptomatic bacteriuria, causative pathogens and antibiotic sensitivity pattern in antenatal women.

Abstract

Objective: To determine the frequency of asymptomatic bacteriuria (ASB), causative pathogens and antibiotic sensitivity pattern in antenatal women. Study Design: Cross-sectional study. Setting: Department of Obstetrics and Gynaecology, Nishtar Hospital, Multan, Pakistan. Period: February 2022 to July 2023. Methods: A total of 110 women with singleton pregnancy with gestational age 13-42 weeks, and aged 18 to 40 years were included. Once the patients were enrolled, demographic characteristics (age, gestational age, parity (primiparous or multiparous), body mass index (BMI), place of living (rural or urban), gestational diabetes mellitus (yes or no), educational status (illiterate, primary, middle, matric, or graduate)) were noted. Presence or absence of asymptomatic bacteriuria was noted. Results: In a total of 110 pregnant females, the mean age and gestational age were 28.7±3.9 years and 29.4±4.0 weeks, respectively. The frequency of ASB among pregnant women was found in 19 (17.3%) patients. The frequency of causative pathogens showed that E. coli was the most frequent isolates noted among 7 (36.8%) women while staphylococcus aureus, Klebsiella, pseudomonas spp, and Proteus spp were identified in 5 (26.3%), 4 (21.0%), 2 (10.5%), and 1 (5.26%) respectively. Antibiotic susceptibility patterns revealed that Amikacin, Nitrofurantoin, cephalexin, and Ciprofloxacin were the most sensitive antibiotics noted in 18 (94.7%), 17 (89.5%), 15 (79.0%) and 14 (73.7%) samples respectively. Conclusion: The frequency of asymptomatic bacteriuria in pregnant women is high with E. coli as the most common causative organism. Antibiotic susceptibility patterns revealed that Amikacin, Nitrofurantoin, cephalexin, and Ciprofloxacin to have good sensitivities.