Relationship between Vitamin D and parathyroid hormone levels along with simvastatin effect on serum calcium levels in postmenopausal women with osteoarthritis.

Abstract

Objective: To investigate the relationships between vitamin D, PTH, and Simvastatin and their effects on serum calcium levels in postmenopausal women with OA. Study Design: Cross Sectional study. Setting: Nowshera Medical College, Nowshera. Period: Six Month January to June, 2022. Material & Methods: Ethical approval was obtained, and 24 postmenopausal women with osteoarthritis (OA) were recruited. Morning blood samples were collected, processed, and stored for analysis of 25(OH) D, calcium, and PTH levels. Plasma samples were acquired 3 hours after Simvastatin administration and data analysis was performed using SPSS 17.0, with significance set at p < 0.05. Results: In this study, 24 postmenopausal women with osteoarthritis exhibited an average age of 53.4 years, with vitamin D levels at 18.7 ng/ml and consistent serum calcium levels at 9.1 mg/dl. Parathyroid hormone (PTH) levels varied widely, averaging 52.8 pg/ml. Analysis revealed that vitamin D and PTH increased serum calcium level while the combination of vitamin D with Simvastatin and PTH with Simvastatin exhibited a nuanced relationship, resulting in a moderated decrease in blood calcium levels. Conclusion: This study sheds light on the intricate interplay between vitamin D, PTH, and Simvastatin in postmenopausal women with OA, offering valuable insights for tailored treatment approaches in OA management.