NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

FREQUENCY IN DIABETES MELLITUS (TYPE II) PATIENTS AND NON DIABETIC GROUP AT SHALAMAR MEDICAL AND DENTAL COLLEGE, LAHORE

Abstract

Objectives: To assess the incidence of NAFLD and biochemical profile in nondiabetic
and diabetic patients. Study Design: It was a cross sectional descriptive study. Setting:
Shalamar Institute of Health Sciences (SIHS), Lahore. Period: Six months, Jan 2015 to Jun
2015. Methods: The patients coming to the Radiology Department for abdominal ultrasound
were age and sex matched into fatty liver and non-fatty liver groups and diabetic and nondiabetic
groups and were further evaluated on the basis of glucose, alanine aminotransferase
(ALT) and triglycerides (TG) levels from the laboratory data. Results: The findings of all
biochemical parameters were raised in diabetic patients with fatty liver as well as in non-fatty
liver diabetic group and the differences were found to be statistically (P value less than 0.05)
significant. In non-diabetic group, out of 200 subjects 56.5% had NAFLD whereas 43.5% had
no NAFLD. In diabetic patients, out of 200 patients 69% had NAFLD and 31% had no NAFLD
and the difference was significant statistically (P= <0.05). The prevalence of NAFLD 12.5%
was higher in type-2 diabetic patients as compared to non-diabetic group. In non-diabetic
group, 113 subjects had TG value of 181±82.49, while 87 subjects had TG of 141±44.5. In
diabetic patients, 138 patients had TG value of 467±277.64 whereas 62 patients had TG value
of 178±46.52, which was statistically significant (P= <0.05). Conclusion: Fatty liver is an
important marker for metabolic syndrome which is a pre-diabetic condition. The occurrence
of NAFLD was elevated in type II patients of diabetes. The traditional risk factors for NAFLD
are considered to be female sex, type II diabetes mellitus, obesity and hypertriglyceridemia.
Hyperglycemia, hypertriglyceridemia and elevated ALT were observed more repeatedly in fatty
liver than in non-fatty liver (type II) diabetic patients