Diagnostic accuracy of Non Invasive Imaging “Ultrasound Elastography” in Breast Carcinoma in Patients with Pathological Nipple Discharge Taking Histopathology as Gold Standard.

Abstract

Objective: To evaluate the diagnostic accuracy of Strain Elastography in detection of breast carcinoma taking histopathology as gold standard. Study Design: Cross sectional study. Setting: Department of Radiology, Liaquat University of Medical and Health Sciences, Jamshoro. Period: June 2021 to May 2022. Methods: Patients aged 25 to 65 years with clinically palpable breast lump of any size with pathological nipple discharge. This study was conducted from June 2021 to May 2022 in department of radiology. Each patient will be subjected to sonoelastography followed by ultrasound guided trucut biopsy. The strain ratio cut off value of 4.8 will be used to differentiate benign from malignant lesion. Results of Strain Elastography will be compared with histopathology reports. Result: Mean age was 37.40 ±11.54 years. The sonoelastography showed sensitivity of 88.57%, specificity of 90.20%, positive predictive value of 75.61% and negative predictive value of 95.83%. So diagnostic accuracy of sonoelastography was 89.78% in diagnosis of malignant breast lesions. Conclusion: Sonoelastography has good sensitivity and specificity in diagnosis of malignant breast lesions.