Correlation between hepatomegaly and transfusion frequency in thalassemia patients: A cross-sectional study.


  • Adeel Rehman Isra University, Hyderabad.
  • Kumayl Abbas Meghji Isra University, Hyderabad.
  • Haji Abdullah Memon Isra University, Hyderabad.
  • Ahmed Mustafa Burney Isra University, Hyderabad.
  • Wasi Ur Rehman Siyal Bilawal Medical College, LUMHS, Jamshoro.
  • Muhammad Jawad Ziauddin Medical College, Karachi.



Thalassemia, ß-Thalassemia Major,, hepatomegaly, iron overload, hemoglobinopathies, Blood Transfusion


Objective: To investigate the relationship between transfusion frequency, serum ferritin levels, and hepatomegaly in beta-thalassemia major patients. Study Design: Cross-sectional study. Setting: Thalassemia Center, Liaquat University Hospital, Hyderabad. Period: January 2023 to June 2023. Material & Methods: Among 158 patients, age until 19 years, and β-thalassemia type major was considered as inclusion criteria. Data regarding hematological parameters and hepatomegaly was collected after informed consent. Data was analyzed using SPSS (version 22). Chi-square test was used to investigate the association between ferritin levels and hepatomegaly while Pearson’s correlation was used assess the correlation between ferritin levels and transfusion frequency. P-Value ≤ 0.05 was considered as statistically significant. Results: Majority of the participants were males (58.22%) as compared to females (41.77%). The mean age of the study participants was 9.31±4.47 years, and the mean age at first transfusion was 8.98±0.93 years. Majority of the participants were underweight 107(67.72%). Monthly transfusion rate was 1.95±0.31.The mean serum ferritin levels among the study participants were 2033.06±1309.36 ng/mL. Hepatomegaly was found to be present in 99 (62.65%) of the study participants. Statistically significant positive correlation between the frequency of transfusion and serum ferritin levels (r = 0.71, p<0.05) was observed. The difference of hepatomegaly in low-ferritin vs high-ferritin was also found to be statistically significant (p<0.05). Conclusion: It was concluded that higher transfusion rates were associated with elevated ferritin levels, and there was a significant association between higher serum ferritin levels and the presence of hepatomegaly.

Author Biographies

Adeel Rehman, Isra University, Hyderabad.

Fourth Year MBBS Student, 

Kumayl Abbas Meghji, Isra University, Hyderabad.

M. Phil, Assistant Professor Physiology, 

Haji Abdullah Memon, Isra University, Hyderabad.

Fourth Year MBBS Student, 

Ahmed Mustafa Burney, Isra University, Hyderabad.

Fourth Year MBBS Student, 

Wasi Ur Rehman Siyal, Bilawal Medical College, LUMHS, Jamshoro.

Second Year MBBS Student, 

Muhammad Jawad, Ziauddin Medical College, Karachi.

Fourth Year MBBS Student,