Gender as a threat for type 2 diabetes mellitus: Elevated fasting glucose, insulin, and HOMA-IR levels in females.

Abstract

Objective: The research aimed to compare serum levels of fasting plasma glucose, 2hrpp, fasting insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and waist-to-height ratio in individuals with a diabetic background. Study Design: Cross-sectional Observational draft. Setting: District Headquarters Hospital, Gujranwala. Period: December 22, 2020, to December 22, 2022. Material & Methods: Overall, 80 healthy participants, 20-50 years old, were recruited and graded into two groups based on gender. Group A comprised males, and Group B comprised females. All participants demonstrated normal glucose tolerance centered on the oral glucose tolerance test. Results: Females exhibited significantly higher mean levels of fasting plasma glucose (p=0.01), fasting plasma insulin (p=0.004), and Homeostasis Model Assessment of Insulin Resistance (p=0.007) compared to males. Homeostasis Model Assessment of Insulin Resistance and waist-to-height ratio exhibited a positive correlation (p=0.001). Conclusion: Females with a positive family history may present an amplified threat of Type 2 Diabetes Mellitus.