Microalbuminuria as a risk factor for ischemic cerebrovascular diseases in essential hypertension- a case control study.

Abstract

Objectives: To determine whether Microalbuminuria, is a risk factor for ischemic cerebrovascular diseases, in our patients with essential hypertension. Study Design: Case Control study. Setting: Department of Medical, Khyber Teaching Hospital, Peshawar. Period: 28^th July, 2022 till 28^th February, 2023. Material & Methods: After taking no objection certificate from Institutional Review and Ethical Board (IREB) as per notification No 738/DME/KMC, all those patients, who were fulfilling our inclusion criteria, got admission to the medical ward, for determination of microalbuminuria, their urine was collected for 24 hours. The patients were divided into two groups, one without cerebrovascular disease (CVD) and other with CVD. Data of all patients was recorded on a predesigned proforma. Results: Amongst the total of 200 patients enrolled, 58(29%) patients’ age was in range of 16-40 years and 142(71%) patients’ age was in range of 41-120 years. Mean age of our patients was 53 years with standard deviation ± 20.12. As far as gender is concerned, 110(55%) patients were males and 90(45%) patients were females. Approximately 83(41.5%) patients had microalbuminuria and 110(58.5%) patients had no microalbuminuria. Only hypertension but no CVD was present in 145(72.5%) patients, while 55(27.5%) patients had hypertension and CVD, 47.47% of these, had microalbuminuria. Conclusion: Amongst the hypertensive patients, microalbuminuria was present in significantly higher number of patients with ischemic Cerebrovascular Disease as compared to patients who had no cerebrovascular disease.