Frequency of maternal high serum hs-C reactive protein level in pre-eclampsia patients.

Abstract

Objective: To determine the frequency of high serum high-sensitivity C-reactive protein (hs-CRP) level in pre-eclampsia women. Study Design: Cross-sectional study. Setting: Department of Obstetrics and Gynaecology, Bahawalpur Medical and Dental College, Bahawalpur. Period: October 2022 to February 2023. Material & Methods: A total of 206 women aged between 20-35 years with singleton pregnancy, gestational age >20 weeks, any parity, and pre-eclampsia were analyzed. High serum hs-CRP was defined as when serum hs-CRP was above 7.0mg/L. The patient was diagnosed with pre-eclampsia when she had systolic blood pressure ≥140mmHg, measured at two different intervals after 20 weeks of pregnancy and proteinuria (200 mg or more per 24-hour period) by laboratory test. The frequency of high hs-CRP was noted. Results: In a total of 206 females, the mean age was 29.69±3.12 years while 120 (58.3%) were aged between 18-30 years. The mean gestational age and parity were 27.83±2.64 weeks and 2.65±1.44 respectively. Frequency of high serum hs-CRP was noted in 135 (65.5%) females with pre-eclampsia. It was found that age (p=0.686), gestational age (0.253) and parity (p=0.927) were not having any statistically significant association with high serum hs-CRP. BMI was noted to have significant association with high serum hs-CRP (p<0.001). Conclusion: The frequency of high maternal hs-CRP was very high (65.5%) among females with pre-eclampsia.