Comparison of seroma formation between flap and non-flap fixation technique of mastectomy for different stages of breast cancer.


  • Ammarah Zia Holy Family Hospital.
  • Sehrish Siddique Holy Family Hospital.
  • Sidra Mehmood Dar Holy Family Hospital.
  • Jahangir Sarwar Khan Holy Family Hospital.



Flap Fixation, Mastectomy, Seroma Formation


Objective: To compare the effect of flap fixation and non-flap fixation for preventing seroma formation depending upon stage of surgery in patients undergoing mastectomy at RMU Allied Hospitals following mastectomy in our local population. Study Design: Randomized Controlled Trial. Setting: Surgical Units of Holy Family Hospital, Benazir Bhutto Hospital, DHQ Hospital (RMU & Allied Hospital). Period: October 2020 to April 2021. Material & Methods: Sample size of 114 cases was included in the study. It was Non probability, consecutive sampling technique. Patients were equally randomized to flap-fixation (Group A) and non-flap fixation (Group B). Patients of both groups were followed up to 48 hours postoperatively for seroma formation. Results were analysed using SPSS software and compared by applying chi-square test and p-value ≤0.05 considered significant. Results: Statistically significant difference (p-value ≤0.05) for seroma formation was noted only in disease stage IIIA. In group A (Flap Fixation), seroma formation was noted in 22.8% (n=13) patients, while in group B (Non-Flap Fixation) it was noted in 45.6% (n=26) patients only. Conclusion: The patients with stage IIIA undergoing mastectomy are significantly (p-value ≤0.05) associated with seroma formation. Whereas, flap fixation is more useful technique for minimizing seroma formation.

Author Biographies

Ammarah Zia, Holy Family Hospital.

MBBS, FCPS (Surgery), Senior Registrar Surgery, 

Sehrish Siddique, Holy Family Hospital.

MBBS, FCPS (Surgery), MRCPS (Glasgow), Senior Registrar Surgery, 

Sidra Mehmood Dar, Holy Family Hospital.

MBBS, FCPS (Surgery), Senior Registrar Surgery, 

Jahangir Sarwar Khan, Holy Family Hospital.

MBBS, FCPS, FRCS, FICS, FACS, Dip. Med Edu, Professor Surgery,