Presence of concurrent derangements of liver function tests in type 2 diabetes: A retrospective observational study.


  • Ayesha Siddiqa PIMS.
  • Sara Khan CMH, Bahawalpur.
  • Maryam Rafiq Sahiwal Medical College, Sahiwal.
  • Nudrat Fayyaz MMDC, Multan.
  • Farah Hanif PIMS, Islamabad.
  • Muhammad Fiaz PIMS, Islamabad.



ALT, Diabetes, Deranged, Liver Function Test


Objective: To know the frequency of deranged liver functions in patients with diabetes mellites and to ascertain the association between two conditions. Study Design: Retrospective Cross-sectional study. Setting: Department of Pathology Shaheed Zulfiqar Ali Bhutto Hospital. Period: 1st January, 2020 to 1st January, 2021. Material & Methods: All patients with diabetes and deranged liver functions were included in the study. Ethical approval was taken from the hospital ethical committee. Data was entered into the predefined proforma. Data was collected from hospital laboratory system. Data analyzed by using SPSS and p value of ≤ 0.05 was taken as significant. Results: In this study 102 people of both genders were included, out of these 62 were diabetic patients and 40 were age matched controls. Deranged liver function test was present between 39.20% and among these raised ALP was noted in 19.60%, ALT in 14.70% and total bilirubin in 4.90%. Liver function tests were compared between gender, and it was found that total bilirubin was significantly different between two groups. Conclusion: It can be concluded from the study that diabetes is associated with liver function derangement. ALT is significantly high in diabetic patients compared to controls.

Author Biographies

Ayesha Siddiqa, PIMS.

MBBS, FCPS, CHPE, Assistant Professor Pathology, 

Sara Khan, CMH, Bahawalpur.

MBBS, FCPS, MHPE, Assistant Professor Pathology, 

Maryam Rafiq, Sahiwal Medical College, Sahiwal.

MBBS, FCPS, Assistant Professor Pathology, 

Nudrat Fayyaz, MMDC, Multan.

MBBS, FCPS, CHPE, Associate Professor Pathology, 

Farah Hanif, PIMS, Islamabad.

MBBS, MCPS, M.Phil (Hematology), Assistant Professor Pathology, 

Muhammad Fiaz, PIMS, Islamabad.

Ph.D, Medical Technologist Pathology,