GUILLAIN BARRE SYNDROME;

Clinical feature in children

Abstract

Background: Guillian Barre Syndrome is a polyradiculopathy characterized by symmetric ascending paralysis and
areflexia. It affects all age groups and both sexes with an unpredictable outcome. Objectives: The aims of this study were to identify the
various diseases presenting as Acute Flaccid Paralysis and notice clinical features and outcome of cases of Guillian Barre Syndrome.
Materials and Methods: Retrospective analysis of 53 patients presenting as Acute Flaccid Paralysis was done. Clinical features and
laboratory investigations of 39 patients of Guillian Barre syndrome were reviewed. Results: Among all cases of Acute Flaccid Paralysis,
Guillian Barre syndrome formed the bulk of the cases (73.6%).It was more common in females and in age group of 10 years or below. In
majority of the cases, rapid onset of weakness was the initial symptom. Mortality was 100% in patients who had respiratory muscle
involvement and who required mechanical ventilation. Conclusions: In our study the main factor causing death in a case of Guillian Barre
syndrome was bulbar involvement requiring mechanical ventilation. Early recognition of the prognostic factors may lead to decreased
mortality in case of Guillian Barre syndrome.