Anti hyperlipidemic effect of Oxyresveratrol and Zinc complex versus simvastatin on Total Cholesterol in Hyperlipidemic rat Model.

Abstract

Objective: To determine the Anti hyperlipidemic effect of Oxyresveratrol and Zinc complex on Total Cholesterol in Hyperlipidemic rat Model. Study Design: Experimental study. Setting: Islamic International Medical College Rawalpindi. Period: Sep 2020 to Sep 2021. Material & Methods: In our study on high fat diet fed hyperlipidemic rats comparison of this standard drug with a novel compound oxyresveratrol was done. Forty rats were randomly divided into 4 groups, Group I was used as NC (Negative Control), group II Positive Control (PC), group III (OXY-Zn complex) and group IV SIM respectively. Groups III and IV were given orally 10 mg/kg body wt. OXY-Zn and SIM respectively. Terminal sampling was performed on day 57 for estimation of total cholesterol. Results: OXY-Zn complex showed significantly better control over total cholesterol compared with SIM. Total cholesterol of OXY treated group showed p < 0.001 like SIM treated group (p < 0.001). Conclusion: Our results showed that OXY-Zn complex is better than simvastatin because of its significantly positive effect on total cholesterol when compared with SIM.