Pattern of bone metastasis; Central VS. Peripheral skeleton in metastatic breast carcinoma.


  • Fariha Ahmed Nishtar Hospital, Multan.
  • Aamir Shahzad Nishtar Hospital, Multan.
  • Waseem Abbas Nishtar Hospital, Multan.
  • Sidrah Mahmood Multan Institute of Nuclear Medicine and Radio Therapy, Multan.
  • Khadim Hussain Nishtar Hospital, Multan.
  • Muhammad Sabir Nishtar Hospital, Multan.



Breast Carcinoma, Bone Metastasis


Objective: To see the pattern of bone involvement in metastatic breast carcinoma. To study the distribution of bone metastasis, central skeleton vs. peripheral skeleton, in metastatic breast carcinoma. Study Design: Retrospective study. Setting: Department of Surgery, Nishtar Medical University, Multan, in accordance with Breast Clinic MINAR. Period: March, 2021 to August, 2022. Material & Methods: The study was done in breast clinic MINAR, Multan. It was retrospective, non-randomized and single institution based study. The female patients who presented with breast carcinoma from March 2021 to August 2022, aged 25 to 70 years were scrutinized. Among these, the patients with metastatic breast carcinoma having metastasis in bones, confirmed on bone scan, were included in the study. 90 cases were collected in this research. The tumours which primarily arise from bone, lymphoid tumours, soft tissue tumours and bone marrow tumours and bone metastasis due to malignancies arising from other visceral organs were excluded. All the data was entered and analyzed using computer programme SPSS version 25.0. Results: The highest range of patients were between ages of 46-65 years. 87.8% were married, 2.2% were unmarried and 10% were divorced or widow. 43.3% were from rural area and 56.7% were from urban area. 93.3% previously had not any history of breast carcinoma. Only 6.7% had family history of breast carcinoma. 64.4% had menarche during the age of 12 to 14 years. And 42.2% had menopause between 50 to 55 years. While in all these cases 46.7% were those who had no menopause at all when they presented with metastatic breast carcinoma. Among these 13.3% had solitary bone metastasis and 86.7% had metastasis to multiple bones. 46.7 % had central or axial skeletal involvement, 13.3% had peripheral skeletal involvement and 40% had both, including central and peripheral skeleton. Conclusion: This study has shown that among all the patients there were 46.7% patients had central skeletal involvement and 13.3% had peripheral skeleton involvement and 40% had both.

Author Biographies

Fariha Ahmed, Nishtar Hospital, Multan.

MBBS, FCPS, Senior Registrar Surgery, 

Aamir Shahzad, Nishtar Hospital, Multan.

MBBS, FCPS, Senior Registrar Surgery, 

Waseem Abbas, Nishtar Hospital, Multan.

MBBS, FCPS, Medical Officer Surgery, 

Sidrah Mahmood, Multan Institute of Nuclear Medicine and Radio Therapy, Multan.

MBBS, FCPS, Consultant Radiology, 

Khadim Hussain, Nishtar Hospital, Multan.

MBBS, FCPS, Senior Registrar Surgery, 

Muhammad Sabir, Nishtar Hospital, Multan.

MBBS, FCPS, Assistant Professor Surgery,