Serum Uric acid in essential hypertension and its correlation with left ventricular hypertrophy.

Abstract

Objective: To estimate serum uric acid in essential hypertension and its correlation with left ventricular hypertrophy (LVH) in patients presenting at a tertiary care hospital. Study Design: Cross Sectional study. Setting: Department of Cardiology and Medicine, BMC Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad and NICVD Hyderabad, Sindh. Period: July 2018 to January 2021. Material & Methods: A sample of 100 diagnosed cases of essential hypertenison (group A), 100 essential hypertenison with LVH cases (group B) and 100 age matched healthy control (group C) was selected through non- probability convenient sampling. Echocardiography findings of cases and control were noted. Serum uric acid, urea and creatinine were measured form sera. LVH was defined by Devereux’s formula. Continuous variables were analyzed Student`s Independent samples t – test and Pearson`s correlation was used for essential hypertension and LVH on SPSS ver. 21.0 at 95% Confidence interval (P≤0.05). Results: Serum uric acid in EH, EH+LVH and controls was noted as 5.5±1.0, 5.8±1.9 and 3.81±1.2 mg/dl (P-0.0001). LV in EH, EH+LVH and controls was measured as 10.8±2.3, 16.4±3.3 and 9.6±0.2 mm in 3 study groups (P-0.0001). Uric acid proves statistically significant linear correlation in EH+LVH revealing positive correlation (r=0.475), (P=0.0001). Conclusion: The present study reports serum Uric acid is found elevated in essential hypertension and essential hypertension with left ventricular hypertrophy. Uric acid shows positive correlation with left ventricular hypertrophy.