Relationship between Apolipoproteins, Lipoprotein (a) and conventional cholesterol and lipids with insulin resistance.


  • Sikandar Hayat Khan PNS Hafeez.
  • Ahmed Hayat Afzal Liaquat National Medical College,
  • Rahat Shahid SHAHID PNS Hafeez,
  • Robina Manzoor PNS Hafeez Hospital.



Apo-A1, Apo-B, Fasting Triglycerides, HOMAIR, HDL-Cholesterol, Lipoprotein (A), LDL-Cholesterol, Total Cholesterol


Objective: To evaluate Apo-A1, Apo-B and Lipoprotein (a) and conventional lipid profile parameters among subjects with high and low insulin resistance groups. Study Design: Cross Sectional study. Setting: Naval Hospital, Islamabad. Period: 2018 to 2020. Material & Methods: To include 164 subjects after several exclusions. We carried out conventional lipid indices along with serum insulin, Apo-A1, Apo-B and Lp (a) on these subjects after formal permission. We calculated insulin resistance by using the the HOMAIR index. Results: Male population demonstrated higher Apo-B [(Male: 66.44+21.75) vs (Female: 60.84+19.96), p=0.095], triglycerides [(Male: 2.29+1.35) vs (Female: 1.84+0.93), p=0.014] while male showed lower Lp (a) [(Male: 126.13+9.15) vs (Female:16.60+9.39), p=0.095] and Apo-A1. 126.13+21.97) vs (Female: 135.34 +25.24), p=0.017]. Apo-A1 showed highest but still weak positive correlation with HDLc, while Apo-B demonstrated higher positive correlation with total correlation, triglycerides, LDLc, non-HDLc and Lp (a). Among comparison between high and low insulin resistance groups, we could only demonstrate significant differences between triglycerides [Low insulin resistance group: 1.94+1.15 vs High insulin resistance group: 2.41+1.29, p=0.019] and Apo-A1 [Low insulin resistance group: 132.54+23.16 vs High insulin resistance group: 124.91+24.17, p=0.050]. Conclusion: Apo-B demonstrated higher positive correlation with total correlation, triglycerides, LDLc, non-HDLc and Lp (a). There were significant differences for triglycerides and Apo-A1 between insulin resistance groups. Female gender and higher insulin resistance groups demonstrated higher Apo-A1 levels.

Author Biographies

Sikandar Hayat Khan, PNS Hafeez.

MBBS, FCPS (Chemical Pathology), MSc Molecular Pathology & Genomics (UK), PgD Endocrinology Diabetes (UK), Certificate Clinical Research, Certification Healthcare Professional Education (UK), Assistant Professor Pathology, 

Ahmed Hayat Afzal, Liaquat National Medical College,

Medical Student, 

Rahat Shahid SHAHID, PNS Hafeez,

MBBS, FCPS (Radiology), Professor Radiology, 

Robina Manzoor, PNS Hafeez Hospital.

MBBS, FCPS (Gynecology), Consultant Gynecology,