Effect of curcuma longa on atherogenic index of plasma in alloxan induced diabetic rats.

Abstract

Objective: To determine effects of Curcuma longa (CL) on the glycemic control, blood lipids and atherogenic index of plasma (AIP) in alloxan induced diabetic male Wistar albino rat model. Study Design: Experimental study. Setting: Department of Basic Medical Sciences, Suleman Roshan Medial College, Tando Adam, Sindh. Period: February 2019 to January 2021. Material & Methods: A sample of 100 rats was divided into negative controls (C^-), positive (diabetic) control (C⁺), and experimental groups D, E and F. DM was induced by injecting Alloxan (120 mg/Kg body weight) intraperitoneally (i.p) to overnight fasting rats. Diabetic groups D, E, and F were treated with ethanol extract of Curcuma longa 100 mg, 300 mg and 500 mg orally daily for six weeks. Blood samples were collected for biochemical analysis. Atherogenic Index of Plasma (AIP) was calculated by log TAG/HDLc. Data analyzed on SPSS package (ver. 21.0, IBM, incorporation, USA) (p≤ 0.05). Results: Significant improvement in glycemic status and blood lipids was observed in Curcuma longa treated groups D, E and F (P=0.0001). Atherogenic index of plasma (AIP) in negative (C^-) and positive (C⁺) control was 0.08±0.03 and 1.11 ±0.1 respectively (P=0.0001) that improved in Curcuma longa treated groups D, E and F noted as; 0.77±0.3, 0.68±0.3 and 0.62±0.4 respectively. Conclusion: Present study found ethanolic extract of Curcuma longa improves the glycemic control, lipid profile and atherogenic index of plasma (AIP) in alloxan induced diabetic rat model.