Assessment of plasma MPO and cTnI levels in patients with cardiac chest pain of 4-6 hours duration.

Abstract

Objective: To assess the plasma MPO and cTnI levels in patients with cardiac chest pain of 4-6 hours duration. As cardiac troponins rise late almost 6-8 hours after the onset of myocardial infarction, another marker is needed to make earlier diagnosis and in those where ECG findings are nonspecific. Study Design: Cross Sectional study. Setting: Emergency Department and Central Laboratory of Punjab Institute of Cardiology (PIC) Lahore. Pathology Department and Central Laboratory of Postgraduate Medical Institute (PGMI)/ Lahore General Hospital (LGH)/ Ameer ud Din Medical College (AMC) Lahore. Period: January 2018 to December 2018. Material & Methods: Eighty subjects were selected who presented with typical chest pain. Two samples from each subject were taken, first sample for MPO within two hours and the second sample for cTnI four to six hours after the start of chest pain. MPO samples were taken in ethylenediaminetetraacetic acid (EDTA) and cTnI samples in heparin tubes. Results: Out of 80 patients, the mean age was 56.40 + 11.39 years. Only one (1.2%) patient was found positive (MPO > 5 u/ml) and the mean MPO was 2.10 + 1.35 u/ml. Among these patients, 25.0% had 0.04-0.3 ng/ml (suspected ischemia) while majority 65.0% patients had cTI >0.3 ng/ml (positive) and mean cTnI was 5.42 + 1.16 ng/ml. Conclusion: MPO samples taken within two hours of chest pain, 1.2% patients were positive. Tests carried out for cTnI taken four to six hours after chest pain, 65.0% patients were positive.