SUBCLINICAL HYPOTHYROIDISM;

Frequency in chronic kidney disease patients before dialysis.

Abstract

Chronic kidney disease (CKD) is characterized by progressive destruction of renal mass with irreversible sclerosis and
loss of nephrons.Various metabolic, hematological and endocrine abnormalities are known to occur in CKD. Subclinical hypothyroidism
is an important endocrine abnormality associated with a greater cardiovascular risk, atherosclerosis and an important factor for
progression of renal disease in such patients. Objective: To calculate the frequency of subclinical hypothyroidism in predialysis CKD
patients. Design: Cross sectional survey. Setting: Pathology Department Post Graduate Medical Institute, Lahore. Period: 06 months
(June 2011 to Dec 2011). Results: 210 patients were included in the study. Serum creatinine. TSH and FT4 were measured and the
relevant data was entered in predesigned proforma. 19.5 % of CKD population had subclinical hypothyroidism with slightly increased
preponderance in females as compared to males and also increased frequency as the stage of CKD increased. Subclinical
hypothyroidism is more common in CKD population. Conclusions: Increased frequency of subclinical hypothyroidism was found in
patients with reduced renal function not on dialysis. 19.5% of CKD population on conservative management had labortary evidence of
thyroid dysfunction.