Platelet-Rich plasma injections treatment in patients having early osteoarthritis of knee joint.

Abstract

Objective: To find out the outcome following intra-articular platelet-rich plasma (PRP) injection in patients having early OA of knee. Study Design: Prospective Study. Setting: Tahira Jamshed Medical Complex, Bahawalpur. Period: January 2019 to February 2020. Material & Methods: A total of 112 cases of both gender, aged 40 to 60 years, Grade I and Grade II OA, having symptoms of OA for a minimum duration of 1 year, were enrolled. All participants were assessed for physical activity and pain linked with arthritis as per “Western Ontario and McMaster University Arthritis Index (WOMAC) score”. Results: Out of a total 98 cases who completed the study, majority 58 (59.2%) were female, 67 (68.4%) had Kellgren-Lawrence Grade-I OA and 81 (82.7%) were experiencing OA symptoms with a duration of less than 2 years. The difference between mean WOMAC score before the treatment (80.38+6.3) and after PRP treatment (42.93+6.9) turned out to be statistically significant (p value < 0.001). After the treatment, cases having duration of symptoms of OA as less than 2 years had significantly less WOMAC score (p value = 0.0418). Conclusion: PRP treatment in patients having early OA seemed to be quite efficacious. The effects of PRP injections were more favorable in cases having clinical symptoms of OA for less than 2 years of duration.