VITAMIN-D DEFICIENCY DURING PREGNANCY;

Serum 25 hydroxy vitamin-D level is the best predictor.

Abstract

Objective: To find out the frequency of vitamin-D deficiency during pregnancy by using Serum 25 hydroxy vitamin-D3 level
and to evaluate the risk factors associated with low level of vitamin-D. Study Design: Cross Sectional Study. Setting: Gynae and obstetric
unit II in Abbasi Shaheed Hospital Karachi. Period: February 2011 to July 2011. Material and methods: Design: All patients with history
of chronic renal disease, liver disorder, PIH, GDM, twin gestation, anti tuberculous treatment and antiepileptic treatment with excluded.
Data was collected by predesigned proforma through personal interview. Result: This study showed 49 cases (98%) of primigravida
were vitamin-D deficiency. The highest low level was in 15-25 years of age. The mean concentration of 25bOH vitamin-D 3 was 10.30ng
/ml.60 % of women had severe vitamin-D deficiency with level of 25 OH vitamin-D3 was lessthan 10ng/ml. Risk factors associated with
low level of vitamin-D3 included dietary deficiency , lack of sun exposure and practicing veil. Conclusions: Pregnant women including
primigravida in Pakistan are at risk of vitamin-D deficiency. 25 (OH) assay should be used as an aid in assessment of vitamin-D deficiency
during pregnancy so that proper correction can be achieved. Women who are deficient in vitamin-D should be counseled regarding
maternal and neonatal risk, a balanced diet ,limited sun exposure and compliance of vitamin-D supplement to ensure normal maternal and
fetal outcome. Every women should provided by vitamin-D supplement prior to pregnancy.