FREQUENCY OF DISLIPIDEMIA.

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Abstract

Background: Lipid lowering therapy in documented Coronary artery disease
is considered secondary prevention and lipid levels have significant influence on CAD Death
rates. Objectives: To find out the frequency of dyslipidemia in patients of ischemic heart disease
patients and to compare the results with international studies. Study Design: A descriptive case
series study was carried out. Setting: The study was done in Medical Unit-II and CCU of Allied
Hospital Faisalabad. For 6 months from 15march 2016 to 15 September 2016. Subjects: 50
patients diagnosed to have angina pectoris and ischemic heart disease patients were included.
and all 50 Patients were on routine diet and were asked not to take anything overnight. Blood
sample (5cc) was taken in all 50 patients with overnight fasting and blood sample were sent to
Allied Hospital Laboratory immediately for analysis of (Triglycerides, total cholesterol, LDL and
HDL). Reagents used were those of: “Merck Diagnostia Germany” Triglycerides were measured
by ready to use reagent-using enzymatic splitting with lipoprotein lipase and quinoneimine as
indicator. Total cholesterol, HDL and LDL were measured by “CHOD PAP METHOD” using ready
to use reagents. Methods: Diagnosis was made on the basis of history, clinical examination and
ECG findings. The history included chest pain, palpitation, sweating and shortness of breath.
Ischemic heart disease patients’. ECG criteria were ST segment depression, T-wave flattening
and inversion. All patients were subjected to fasting lipid profile. Results: Out of 50 patients,
30 were males and 20 were females. The frequency of dyslipidemia was 60% in patients of
angina pectoris and ischemic heart disease patients. Triglycerides were elevated in 56 %. Male
were 40% and females 16% and P value regarding gender distribution was 0.063; significant
one indicating that there is a definitive relation between gender and hypertriglyceridemia. Total
cholesterol was elevated in 20%. Males were 12% and females were 8%. And P value regarding
sex distribution was 1.00. LDL was elevated in only 4%. HDL was also elevated in 4% of the
cases. Conclusion: Present study concluded that dyslipidemia is common in angina pectoris
and ischemic heart disease patients especially males and all patients of angina pectoris must be
screened for dyslipidemia as early as possible and should be treated aggressively to minimize
the risk of further complication of angina pectoris.