Association of angiotensin II levels in patients of vasovagal syncope and postural tachycardia syndrome.

Abstract

Syncope occurs as a result of cerebral hypoperfusion. Various neuroendocrine hormones have some role in the pathogenesis of Syncope. Current study was conducted to determine the role of Angiotensin II in pathophysiology of vasovagal syncope (VVS) and Postural tachycardia syndrome (POTS). Study Design: Cross sectional analytical study. Setting: Islamic International Medical College, Rawalpindi and in Electrophysiology department (AFIC). Period: April 2017 to April 2018. Material and Methods: Sample size of this study was comprises of 80 subjects, having 35 cases of VVS and POTS each and 10 controls were also taken. Cases were collected on the basis of Head up tilt test (HUT) result and on their previous history of syncope, then their blood samples were collected and stored. Hormonal analysis of Angiotensin II was performed by ELISA technique. SPSS statistics 21 was used to evaluate result by applying ANOVA test. p value of < 0.05 was considered significant. Result: Analysis of Angiotensin II concentration in Postural tachycardia syndrome, Vasovagal and control group was found 170.93 ± 118.59 pg/ml, 152.16 ± 91.40 pg/ml and 136.93 ± 43.18 pg/ml respectively. In statistical analysis p value was 0.570 which is insignificant. Conclusion: It is concluded that Angiotensin II exerts role in the pathophysiology of VVS and POTS as shown by the difference in the value of Angiotensin II in VVS, POTS and in control group.