Efficacy of velpatasvir and sofosbuvir in treatment of chronic hepatitis C.

Abstract

Objective: To determine the efficacy of sofosbuvir and velpatasvir in treatment of all genotypes of chronic HCV infection. Study Design: Descriptive Case study Setting: Department of Medicine Independent University Hospital Faisalabad. Period: December 2019 to May 2020. Material & Methods: Among patients of chronic hepatitis C presenting in the medical OPD of independent university hospital willing to participate, 80 were included in this study. They were given combination of sofosbuvir and velpatasvir 400/100 mg (FDC) once daily. They were monitored by serum ALT and PCR to HCV quantitative after one month and after three months. End point was undectable PCR to HCV Quantitative. We observed the number of patients achieving SVR after taking combination of sofosbuvir and velpatasvir. Results: In our study, out of 80 cases of chronic hepatitis c 40% (n=32) were male and 60% (n=48) were females, end result revealed 98.8% (n=79) achieved SVR and their PCR remained negative at the end of 03months and 1.3% (n=01) remained positive despite antiviral therapy for 03 months. Conclusion: We concluded that using fixed dose combination of sofosbuvir and velpatasvir achieve SVR of 98.8%.