HYPER PROLACTINAEMIC INFERTILITY

CLINICAL TRIAL FOR THE MANAGEMENT AND COMPARISON BETWEEN TWO TREATMENT REGIMES

Abstract

O BJECTIVE: To compare the success of two therapies, bromocriptine (parlodel) alone and bromocriptine in
combination with clomiphene citrate in the treatment of infertile women with the diagnosis of hyperprolactinaemia
to restore menstruation, onset of ovulation and to achieve pregnancy. DESIGN: Prospective study. SETTING.
Bahawal Victoria Hospital Bahawalpur PERIOD:From1st June 1994 to 30th May 1995(one year study). SUBJECTS:
Total of 58 patients were collected, of which, 18 lost contact in the initial visit, leaving 40 patients for analysis. In
this study the patients included were with the biochemical diagnosis of hyperprolactinaemia associated with irregular,
overdue periods and anovulatory cycles. Amenorrheic women with no evidence of ovarian estrogen production and
elevated FSH levels were excluded. RESULTS: Total 40 patients were divided into two group. One group of 20
patients were given bromocriptine alone. Out of these, 19 patients restored menstruation (95%), 16 patients started
ovulation (80%) and 13 patients conceived (65%).In the second group of 20 patients who were put on bromocriptine
plus clomiphene citrate, the results turned out as restoration of menstruation in all 20 patients (100%),18 started
ovulation(90%)and 15 patients conceived(75%). CONCLUSION: Hyperprolactinaemic infertile patients with
menstrual irregularities and anovulatory cycles (in whom other causes of infertility were carefully excluded) show
better response when clomiphene citrate is administered in combination with bromocriptine as compared to treatment
with bromocriptine alone.