SERODIAGNOSIS OF HELICOBACTER PYLORI INFECTION

Abstract

Myocardial infarction, an increasing plaque of modern society, is a disorder of multifactorial nature. Many cases
of MI have been reported with causes of established cardiovascular factors. This unexplained situation suggests that
there are important unrecognized factors to play a role in the development of myocardial infarction. In this regard
infective agents such as H.pylori is reported to increase the risk of myocardial infarction. Therefore this study was
designed to observe the anti H.pylori antibodies (IgG) and role of H.pylori in myocardial infarction patients, and
comparative study of ELISA technique and ICT (Kit) method, to see their sensitivity, specificity, positive and
negative predictive values in diagnosing the H.pylori infection. The results showed significantly higher levels of IgG
antibodies against H.pylori in myocardial infarction patients, 103 (68.7%) as compared to controls 22 (44%) showing
significant difference (P<0.003). The positive and negative predictive values were 89.1% and 87.5% respectively.
So the study demonstrated no link between H.pylori infection and myocardial infarction. The results of ELISA and
ICT, when compared, are similar showing no significant difference both for patients and controls (P<0.445) and
(P<0.424) respectively. Therefore we concluded that although, ELISA technique is considered goldstandard but it
is time consuming, costly, and quite labour intensive while the ICT method is easy, cheap, give results with in ten
minutes which makes it a fastest test in diagnosing H.pylori infection.