AMLODIPINE AS ANTI-ANGINAL

A CLINICAL TRIAL

Abstract

O BJECTIVE: To study the effects of Amlodipine in angina pectoris patients. DESIGN: Prospective study.
SETTING: Medical Unit II Allied Hospital, Punjab Medical College Faisalabad PERIOD: Total duration was 7
weeks. SUBJECT & METHODS: Twenty patients with symptomatic chest pain were included and were assessed
for seven weeks. This assessment was made by the number of glyceryl trinitrate (GTN) tablets required per week.
RESULTS: Out of 20 patients , 12 were male and 8 were female having mean age of 54.7 years. A mean height was
165.3 cm and mean weight was 71.4 kg in both sexes. The patients were followed for 7 weeks and were maintained
at 10 mg amlodipine once a day. Significant reduction of anginal attacks was seen i.e. 70% from base line. Use of
nitrates was also reduced as well as reduction in heart rate from 84-78 beats per minute. Amlodipine was well
tolerated and effective. CONCLUSION: This 2 generation dihydropyridine calcium nd antagonist was found to have
both anti hypertensive and anti-anginal property with good safety profile and tolerance.
INTRODUCTION