The Impact of Surfactant Administration Techniques (LISA vs INSURE) on the Outcomes of Respiratory Distress Syndrome in premature babies.

Abstract

Objective: We aimed this study to find out the Impact of Surfactant Administration Techniques (LISA vs INSURE) on the Outcomes of RDS in premature newborns. Study Design: Retrospective study. Setting:  Children’s Hospital and The institute of Child Health Multan. Period: October 2018 to March 2020. Material & Methods: 159 premature babies reported with RDS at Institute of child health, Multan were evaluated. Out of these 87 infants were given surfactant through LISA technique and 72 were given through INSURE. The surfactant used for all these babies was proractant alpha. Results: The duration of oxygen (O₂) therapy was significantly less in LISA group (14.87 ± 11.21 days) as compare to INSURE (19.67 ± 9.79 days), p <0.001. Number of patients who require mechanical ventilation was (23% vs 44%, p< 0.05) and median days of nCPAP was (10.74 ± 3.07 vs 15.12 ± 8.79, p<0.05). Our analysis shows that no significant difference in mortality, incidence of air leak and bronchopulmonary dysplasia (BPD) between the two groups. Conclusion: Patients administered surfactant through LISA technique requires significantly less duration of oxygen therapy and need of mechanical ventilation as well as duration of nCPAP. We conclude that LISA technique is preferable method for surfactant administration in premature infants.