RELATIONSHIP OF CORONARY ARTERY DISEASE (CAD) WITH TOTAL CHOLESTEROL & LDL - CHOLESTEROL/HDL-CHOLESTEROL RATIO

Abstract

Objectives: The purpose of this descriptive study is to determine the significance of measurement of total cholesterol and low density
lipoprotein(LDL)-cholesterol / high density lipoprotein(HDL)-cholesterol ratio and their association with patients of coronary artery
disease(CAD).Methods: The lipid profile of 589 cases including patients aged 20-70 years with coronary artery disease, Ml,
hypercholesterolaemia and normal healthy subjects were investigated to determine the changes in total cholesterol, triglycerides, high
density lipoprotein-C(HDL-C),low density lipoprotein-C(LDL-C) and LDL-C/HDL-C ratio.Enzymatic analysis was done within 24 hours using
Hitachi 704 and 911 auto-analyzer. Results: As expected, LDL-C/HDL-C ratio was higher in the patient group 4(48% in females, 58.8%
in males) than that in healthy group, whereas the HDL-C was lower. Moreover, the mean value of HDL-C, LDL-C and cholesterol in males
was greater than that of females. The LDL-C/HDL-C ratio in hypercholesterolaemic patients(3.1, 34.7%) as less than in CAD/MI
patients(4.49, 73.4%). Also this ratio in Ml group(4.9,93%) was greater than that of CAD and hypercholesterolaemic group.The mean value
of HDL-C in CAD, Ml and hypercholesterolaemic patients was less than that of control group but LDL-C was opposite. Conclusion: We
found that LDL-C/HDL-C ratio is an effective indicator of high risk factor of CAD and in the management of patients suffering from
hypercholesterolaemia. Also it is useful to the clinician when combined with detailed knowledge of the patient's other risk factors. The effect
of disturbances of lipids and lipoproteins on the development of CAD and hypercholesterolaemia patients may also depend on the presence
of other non-lipid risk factors.