EFFECT OF CORONARY ARTERY DISEASE DURATION ON
PLASMA LIPIDS & LIPOPROTEINS CONCENTRATION
DOI:
https://doi.org/10.29309/TPMJ/2003.10.01.5285Keywords:
MI-Myocardial infarction, CAD-Coronary artery disease, LDL-Low density lipoprotein, LDL-C LDL cholesterol, T-HDL-C Total high density, Lipoprotein cholesterol, HDL2-HDL3, Sub fractions of HDL, VLDL-Very low density lipoproteinAbstract
Present study evaluated a new factor i.e. effect of coronary artery disease (CAD) duration on plasma lipids
and lipoproteins concentration. 105 patients of atherosclerotic CAD were divided as: group-A (n=59) having
CAD duration 1 year, group=-B (n=25) and group-C (n=21) having CAD duration 3 years. In group-A, 79%
patients had positive history of vegetable oil use, group-B, 68% and in group-C, 61% patients have positive
history of vegetable oil use in their diet after onset of CAD symptomatology. Results showed that total
cholesterol (TC), LDL and LDL-C which were significantly raised in group-A and B, become nonsignificantly
raised levels in group-C when each group compared with control subject (n=35) while except
significantly decreased levels (p<0.02) of HDL2-C in group-B, all other parameters (TC, triglycerides, LDL,
LDL-C, VLDL-C, THDL-C and HDL-C) showed non-significant difference when compared with group-A.
Non-significant difference in levels also seen in group-C when compared with group- A. Study concluded
that after 3 years of CAD duration TC, LDL and LDL-C levels were decreased. However, this effect may
be depended upon vegetable oil use. While effect of CAD duration on HDL-C levels remained controversial.
