SURGICAL SITE INFECTION

PROPHYLACTIC ANTIBIOTICS IN LAPAROSCOPIC CHOLECYSTECTOMY TO REDUCE SURGICAL SITE INFECTION

Abstract

Objectives: To compare antibiotic prophylaxis in preventing frequency of
postoperative surgical site wound infection rate in low risk laparoscopic cholecystectomy
with controls. Study design: Randomized Controlled Trial. Setting: Department of Surgery,
Combined Military Hospital, Rawalpindi. Duration of study: This study was conducted from
11-07-2015 to 10-01-2016. Subjects and methods: A total of 650 patients (325 in each group)
were included in the study. Patients in group-A received antibiotic prophylaxis whereas patients
in group-B did not receive any antibiotic prophylaxis. Results: Mean age of the patients was
44.91±13.37 and 42.28±13.76 years in group-A and B, respectively. In group-A there were
152 patients (46.7%) and in group-B 148 patients (45.5%) were males. In group-A 173 patients
(53.3%) and in group-B 177 patients (54.5%) were females. In group-A, superficial site infection
was seen in 4 patients (1.2%) and in group-B superficial site infection was observed in 13
patients (4.0%). The difference between two groups was statistically significant (p=0.027).
Mean duration of symptoms was 5.75±0.50 and 5.77±0.92 days in group-A and B, respectively.
Stratification with regard to age, gender and duration of symptoms was carried out. Conclusion:
In conclusion, we recommend the use of pre-operative prophylactic antibiotics for patients
who are undergoing elective low-risk laparoscopic cholecystectomy inorder to prevent postoperative
infectious complications.