AMINO GLYCOSIDES

TOXICITY OF ONCE A DAY DOSING

Authors

  • MAHBOOB AHMED WAGAN P.M.C, Nawabshah.
  • Muhamm ad Baqir Soomro Islamabad.
  • RASHID AHMED SHAIKH Isra University, Hyderabad.
  • Shaheen Shah LUMHS Jamshoro.
  • SYED SAUD HASAN LUMHS Jamshoro.

DOI:

https://doi.org/10.29309/TPMJ/2004.11.01.5263

Keywords:

Amino Glycosides, Once a day, Nephrotoxicity, Gentamicin, Ototoxicity

Abstract

Aminoglycosides are unique protein synthesis inhibitors and are bactericidal. Instead of
three times a day, we gave gentamicin 3 mg/kg once a day, to 10 young patients, whose urine culture report
showed sensitivity to gentamicin. They have an average age of 27 ± 6.5 years. The youngest patient was 19
years old and oldest was 37 years old, having normal creatinine clearance. There was no significant (P>0.05)
change in renal creatinine clearance before and after 7 days of therapy.

Author Biographies

MAHBOOB AHMED WAGAN, P.M.C, Nawabshah.

Assistant Professor Pharmacology,

Muhamm ad Baqir Soomro, Islamabad.

Professor of Anatomy,

RASHID AHMED SHAIKH, Isra University, Hyderabad.

Associate Professor Nephrology,

Shaheen Shah, LUMHS Jamshoro.

Professor of Pharmacology

SYED SAUD HASAN, LUMHS Jamshoro.

Assistant Professor Pharmacology

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Published

2004-03-28

Issue

Vol. 11 No. 01 (2004): Vol 11 No 01

Section

Articles