LYMPHOBLASTIC LEUKEMIA

VARIATIONS IN BIOCHEMICAL PARAMETERS TOXICITY WITH THE TYPE OF INDUCTION TREATMENT

Authors

  • M. ZAHOOR-UL-HASSAN DOGAR Punjab Medical College Faisalabad.
  • M. Farooque Govt. M.C Dispensory Noorpur, Faisalabad.
  • MUNIR A. SHIEKH University of Agriculture Faisalabad.
  • Muhammad Nawaz College of Paramedics, Faisalabad.
  • M. ASGHAR BAJWA University of Agriculture Faisalabad.
  • Farkhanda Almas Population Welfare Department, Faisalabad
  • M. Shoaib Akhtar University of Agriculture Faisalabad.

DOI:

https://doi.org/10.29309/TPMJ/2004.11.01.5260

Keywords:

ALL, Acute Lymphoblastic Leukemia, DVP, Daunorubicin, Vincristine, Predinisolone, ALT, Alanine Transaminase, ALP, Alkaline Phosphatase, Induction Treatment

Abstract

The present study was the continuation of the project in which
two different treatment protocols were applied to evaluate the efficiency of each treatment. 42 total cases were
taken divided equally into two groups. Group 1 was treated by conventional treatment DVP (Daunorubicin +
Vincristine + Predinisolone). In 2 Group DVP nd & L-asparginase enzyme was applied. The effect of two
treatments on various biochemical parameters were studies by taking samples after each 0.5% months during
induction therapy (3 months) and after induction therapy till 6 months. The results showed greater rise in blood
ALT, ALP and amylase levels in Group II, as compared to the findings found in Group I. Similarly a relative
rise in blood glucose, urea and bilirubin was also found in Group II as compared to Group I. It clearly indicates
that after addition L-asparaginase although beneficial for induction therapy but resulted in deleterious effects
development on different vital organs in the body. Its use should be strictly under control of a clinical
biochemist so that its toxicity should not over balance its benefits.

Author Biographies

M. ZAHOOR-UL-HASSAN DOGAR, Punjab Medical College Faisalabad.

Assistant Professor of Biochemistry,

M. Farooque, Govt. M.C Dispensory Noorpur, Faisalabad.

Senior Medical Officer

MUNIR A. SHIEKH, University of Agriculture Faisalabad.

Chairman Department of Chemistry,

M. ASGHAR BAJWA, University of Agriculture Faisalabad.

Assistant Professor of Biochemistry,

Farkhanda Almas, Population Welfare Department, Faisalabad

Deputy Director Technical

M. Shoaib Akhtar, University of Agriculture Faisalabad.

Dean Faculty of Veterinary Science,

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Published

2004-03-28

Issue

Vol. 11 No. 01 (2004): Vol 11 No 01

Section

Articles