PROTEIN METABOLITES; (CREATININE & UREA)

ELIMINATION THROUGH KIDNEYS IN HEALTHY FEMALES

Abstract

The elimination of blood and urinary levels of creatinine and
urea, were determined in healthy volunteers who were on normal diet. Setting: University of Agriculture,
Faisalabad. Objectives: The present study was aimed at analyzing the renal elimination of endogenous
creatinine and urea in healthy females to establish a base line data for the local population. Materials &
Methods: The blood and urine samples of 8 healthy female subjects, collected at appropriate time intervals,
were retained for the determination of endogenous creatinine and urea in them, spectrophotometrically.
Results & Discussion: The mean ± SD concentration of creatinine in plasma of healthy female volunteers
was 9.23± 2.54 μg/ml and in urine 374.08±489.90 μg/ml. Whereas, concentration of urea in plasma was
290.46± 107.27 μg/ml and in urine 27172.80± 4338.45 μg/ml. Creatinine renal clearance was 0.81± 0.49
ml/min/kg (range 0.15-1.18) and urea clearance 9.11± 0.11 ml/min/kg (range 0.04-0.26). These values
existed within the normal range as described in the literature, but a bit lower than values given in the
foreign literature. Conclusion: Creatinine and urea levels in the body are relatively stable. These remain
unchanged unless there is sudden deterioration in renal function.