HEMATOLOGICAL TOXICITY IN RATS;

THERAPEUTIC PROPERTIES OF ANDROGRAPHIS PANICULATA ON OXALIPLATIN INDUCED

Abstract

Objectives: Oxaliplatin causes hematological toxicities in clinical setting which
limits its efficacy. The aim of this study is to investigate the therapeutic effects of Andrographis
paniculata against hematological toxicity caused by oxaliplatin. Study design: Experimental
animal study. Period: Study takes 8 month from March 2015 to Oct 2015. Setting: Dow university
animal house. Method: Wistar albino male rats, divided into 3 equals groups (n=6): Group
N* was a control group (0.9% normal saline), Group NP0 was Oxaliplatin treated group and
Group NP1 was prophylactically treated with Andrographis paniculata followed by Oxaliplatin
in order to assess the protective effects of Andrographis paniculata against the hematologic
toxicity caused by Oxaliplatin. Results: Prophylactic treatment with Andrographis paniculata
(NP1) significantly increases the levels of platelets and neutrophile count compared with the
standard (NP0) (p<0.01) and increases the RBCs count and levels of hemoglobin compared
with the standard (NP0). Conclusion: Prophylactic treatment with Andrographis paniculata
(NP1) was effective in reducing risk of thrombocytopenia, anemia and neutropenia associated
with Oxaliplatin.