CREATININE & UREA LEVELS IN HEALTHY MALES

EVALUATION OF BLOOD & URINE

Abstract

Blood and urinary creatinine and urea levels were determined in
healthy male volunteers. Setting: University of Agriculture, Faisalabad. Objectives: The study was aimed to
have a base-line data regarding elimination of protein metabolites, endogenous creatinine and urea in local male
population. Materials & Methods: Five samples, each of blood and urine from 9 male volunteers, were taken
to determine creatinine and urea in them, spectrophotometrically. Results & Discussion: Blood and urine
samples showed mean ± SD pH values to be 7.2 ± 0.1 and 5.9±0.5, respectively. Whereas mean ± SD
creatinine values were found to be 10.72 ± 3,23 μg/ml and 273.32 ± 330.39 μg/ml, respectively; and mean ±
SD urea to be 303.1 ± 96.7 μg/ml and 26129 ± 3834 μg/ml, respectively. The renal clearance of creatinine and
urea, as determined by glomerular filtration rate, came out to be 0.87 ± 0.51 ml/min/kg and 0.10 ± 0.06
ml/min/kg, respectively. The results revealed normal kidney functions in the subjects as indicated from normal
creatinine and urea values for the local population. However, these values being lower than those in the foreign
literature .Conclusion: Creatinine and urea levels in the body are relatively stable. These remain unchanged
unless there is sudden deterioration in the renal function.