P R O P O F O L A L F E N T A N I L INTUBATION

WITHOUT MUSCLE RELAXANT IN YOUNG ADULT MALES

Abstract

Objectives: To assess the efficacy of propofol & alfentanil
without muscle relaxant in young adults. Design: Prospective double-blind study. Setting: Shiraz University of
Medical Sciences, ( Khalili teaching hospital Shiraz Iran), Period: Aug 2002 to Apr 2003 Material and
Methods: 75 non-athlete adult males scheduled for elective surgery were randomly divided to receive either
succinylcholine 1.5mg/kg (group S), alfentanil 40:g/kg (A-40) or alfentanil 30:g/kg (A-30) in combination
with propofol 2.5mg/kg to induce anesthesia. Results: Hemodynamic responses and intubating conditions were
compared between the three groups. In group S marked increase in MAP and HR occurred after intubation but
A-40 and A-30 patients had subtle changes (p<0.001). Intubating condition was acceptable in all patients of
group S and A-40, but 7 of A-30 group had significant limb movement after intubation. Conclusions:
Alfentanil 40 :g/kg & propofol 2.5mg/kg could provide favourable intubating condition in young adult males.