DIABETES MELLITUS

INTERFERON-$ INVOLVEMENT IN THE ONSET

Authors

  • NASIR MAHMOOD School of Biological Sciences, Quaid-e-Azam Campus, University of the Punjab, Lahore, Pakistan.
  • MUZAFFAR JALAL KHAN NIAZI, K E Medical College, Lahore
  • NASEER AHMAD District Health Development Center (DHDC), Health Department, Jhelum.

DOI:

https://doi.org/10.29309/TPMJ/2005.12.01.5162

Abstract

A number of cytokines have been shown to alter the function of pancreatic
$-cells and thus might be involved in the development of type I diabetes. Objectives: To study whether interferon IFNalters
-cellfunction in vivo and leads to diabetes. Patients & Methods: We have studied three groups of patients (group
I, 20-35, group II, 35-50 and group III, 50-70 years age) taking $-interferon after chronic liver infection due to hepatitis.
Results: 80 % patients in group II and 90 % group III patients particularly showed higher level of blood glucose.
However, only 30 % patients in group I exhibited abnormal level of blood glucose. 20 % patients of group I and 30 %
patients in group II also represented higher level of alanine amino transferase (ALT). Conclusions: These results
suggest that IFN-$ may be involved in the onset of type 1 diabetes and elevated serum alanine amino transferase
(ALT) level.

Author Biographies

NASIR MAHMOOD, School of Biological Sciences, Quaid-e-Azam Campus, University of the Punjab, Lahore, Pakistan.

M.Sc, M.Phil, PGD (CS), PhD

MUZAFFAR JALAL KHAN NIAZI,, K E Medical College, Lahore

Professor of Anatomy (Retd)

NASEER AHMAD, District Health Development Center (DHDC), Health Department, Jhelum.

Program Director,

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Published

2005-03-25

Issue

Vol. 12 No. 01 (2005): Vol 12 No 01

Section

Articles