THE EFFECT OF HALOTHANE

ON BLOOD PRESSURE IN PREMEDICATED AND UNPREMEDICATED PATIENTS

Abstract

Design: Comparative study Setting: In CMH, Kharian and Nishtar
Hospital, Multan. Period: From April 2003 to March 2004. Material & Methods: We studied 100 patients aged 18-45
years undergoing elective surgery. We compared the effects of halothane in two groups, one premedicated and other
unpremedicated on the variability in the blood pressure. Group-I was premedicated with diazepam 5 mg orally and
midazolam 7.5 mg orally, aged between 18-45 years undergoing elective surgery. The blood pressure was monitored
non-invasively in the ward, in the operation theatre during induction and when halothane is switched on. These groups
of patients did not show any significant haemodynamic changes. The blood pressure remained within the normal limits.
The second group of fifty patients underwent elective surgery, but they were not given any above mentioned premedication,
they also belong to same age group. They showed significant haemodynamic changes i.e. rise in blood
pressure and beat to beat heart rate variability. This variability was caused by fluctuating balance of sympathetic and
parasympathetic tone at the sino-artrial node. Statistical analysis was carried out using student “t” test. Differences were
considered significant when P > 0.05 & all values were presented 95 mean (SEM).